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Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights This review provides a comprehensive update of the regulation of midbrain dopamine circuits by peripheral feeding hormones, cataloging what is currently known about the mechanisms by which these hormones influence VTA activity and how these actions regulate food intake and behavior around drugs of abuse

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12 Due to these potential side effects, medical supervision is crucial when initiating and maintaining treatment with semaglutide